
Common Name: Many-headed slime, Grape cluster slime, Slime mold – The many branches that radiate outward from the site of initial growth form clusters at food sources consumed as sustenance. The overall appearance is one of many small nodes that are metaphorically compared to heads.
Scientific Name: Physarum polycephalum – The genus name is from the Greek physarion, meaning small bellows, which may refer to the characteristic pulsating growth which appears to surge as if wind-driven. The species name from Greek poly meaning many and kephalikos (Latin cephalicus) meaning head.[1] The translation literally means many-headed.
Potpourri: Slime molds were saddled with one of the most pejorative names in biology. The Animal Kingdom’s most despicable attribute of slime is sometimes applied to humans as the penultimate insult. The Fungi Kingdom’s worst form is mold, destroyer of agricultural crops and promoter of human respiratory disease. Even so, slime mold is an apt name in describing an unusual form of life. Slime molds bridge the gap between animals and fungi in transitioning from a mold-like spore that then germanites into an amoeba-like animalcule that moves like Lewis Carrol’s “slithy toves”. The onerous task of organizing living things into a comprehensible structure has been a work in progress for centuries. With DNA replacing appearance as its organizing principle, phylogenetics has upended the historical hierarchical taxonomy of Carolinas Linnaeus. This transition is just beginning. Placing slime mold into its proper niche in the web of living things on the TBD list. For now, it is classified as a protist.
Numerous attempts have been made by intellectually curious, sapient humans to impose order on the entangled complexity of their surroundings. Schemes based on geographical locale, patterns of fruits and seeds, and gross morphology were all found to be impractical for field application. Linnaeus had the insightful idea of using sex as the organizational principal for plants, forming 26 categories based on the numbers and arrangement of the (all important) male stamens. Calling them vegetable letters he correlated stamen arrangements to the alphabet as a mnemonic. Praeludia Sponsaliorum Plantarum (Prelude to the Betrothal of Plants) was published in 1730, which garnered international interest that was both supportive and dismissive. Linnaeus forged ahead, and, based on the premise that “Minerals grow; Plants grow and live; Animals grow, live, and have feeling” settled on three kingdoms as his foundation. [2] The inclusion of inanimate rocks as an integral part of the tree of life is testimony to the ignorance of the times.
On December 13, 1735, the first edition of Linnaeus’s Systema Naturae (System of Nature) went on sale in Leyden, Netherlands with a section on the Mineral Kingdom and the Animal Kingdom to supplement the extant alphabetic Plant Kingdom. Minerals were dived into three categories named Petrae for simple stones, Minerae for simple stone mixtures, and Fossilia for aggregate rocky particles (that may or may not have an impression of an animal or plant); the system never made it into the work of Charles Lyell, who correctly classified sedimentary, metamorphic and igneous as the three types of rocks. [3] The Animal Kingdom was to have far reaching impact on the future of biology. Linnaeus devised the canonical format Kingdom, Class, Order, Genus, and Species to establish the first enduring method to catalogue living things into what became known as taxonomy. He identified six classes of animals with 549 species: Quadrupeds (which included the Order Anthropomorpha and thus two-legged humans); Birds; Amphibians; Fish; Insects; and a final class as catchall named Vermes that included everything from reptiles to squid. A seventh group was tacked on at the end named Paradoxa for those animals that were missing from the rankings, as the semi-animal slime mold would have been.
Some twenty kilometers south of Leyden lay Delft, the home of Antonie van Leeuwenhoek, the unlikely father of microbiology. As the owner of a fabric shop, the need for an improved method of magnification to inspect thread quality essential to the drapery business led him to the field of lens grinding, at which he excelled. In fabricating the first practical microscope, he was able to penetrate the heretofore unseen and unknown domain of the minuscule. An investigation of pond water yielded the presence of moving objects which he (correctly) interpreted to be animalcules. Over the course of the next century, as Leeuwenhoek’s hypothesis gained credence, the idea that these ubiquitous simple organisms must represent the origins of life gave rise to the term Protozoa, literally “fist life”. In the modern era, biology has yielded its operating system in the form of DNA coding for protein synthesis. Fungi were added to the kingdom count in the late 20th century (long after rocks had been expelled) but there were still outliers. This gave rise to Kingdom Protista, implying the same notion of first-ness for those living things that were neither animals, nor plants, nor fungi. In addition to the slime molds, protists are inclusive of the animal/plant Euglenoids which are mobile photosynthesis factories, and brown algae aquatic Chrysophytes like kelp. [4]
It is tempting to think of slime mold as an evolutionary alternative that was successful enough to survive but not sufficient for mutation and expansion to higher levels of organization. Slime molds have been referred to as Dr. Jeckel and Mr. Hyde due to similar extremes of form and behavior that a single individual might manifest. [5] The slime mold life cycle starts with a wind-blown spore that germinates under appropriate environmental conditions of temperature, water, and nutrients. Slime mold spores form one of two structures: a blob called a myxamoeba that can divide making multiple copies; or a body called a swarm cell that has a flagellum at one end for locomotion. The sexual union of two compatible myxamoebas or two compatible swarm cells yields a fertilized egg cell or zygote. Individual zygotes fuse into a multi-nucleus structure called a plasmodium that surges back and forth in search of food, the mysterious surging mass occasionally seen on woodland jaunts. When the food runs out or if conditions otherwise deteriorate, fruiting bodies are erected and new spores are ejected to comprise the next generation.[6] Thus, a slime mold can be considered as fungus, plant, or animal according to what stage is considered central. Like the ancient parable of the blind men and the elephant, which is like a snake if one first encounters the trunk but like a spear if one encounters the tusk, slime molds are different things to different people.

Slime molds have traditionally been categorized as myxomycetes from the Greek myxa meaning nasal slime and mykes meaning fungus, a name first applied in 1654. For the next 300 years, fungi were part of the Kingdom Plantae in the Phylum Thallophyta, a collective for primitive plants which also included lichens and algae. Even with sequestration of fungi as the separate kingdom Eumycota, slime molds were considered an integral member. Only recently were they relegated to Kingdom Protista. There are currently about 1,000 species of slime mold taxonomically categorized in 5 orders, 14 families, and 62 genera. [7] Fuligo septica is the best. known of the slime molds. Commonly called either scrambled egg or dog vomit slime (according to age and color) it often grows on garden mulch and can get quite large; a world record F. septica was recorded in Texas in 2016 that was 30 inches long and 22 inches wide. [8] Physarum polycephalum has recently gained the reputation as the slime mold of science due to its demonstrated ability to make what seem to be intelligent choices about the location of food sources and the best way to access them. This is of some interest to developing a better understanding the evolution of cooperation among individual organisms, such as that of social insects like ants and bees.
A scientific experiment conducted at Japan’s Hokkaido University in 2000 found that P. polycephalum was capable of determining the shortest path through a maze that connected two caches of oat flakes, a slime mold favorite.[9] The award of an Ig Nobel prize recognizing this unusual and thought-provoking experiment garnered international slime mold stardom. Ten years later, researchers followed up on the maze trial with a map simulating Tokyo and its many train terminals marked by oat flakes. The objective was to determine if many-headed slime could find the best network route between them. The result, after only 26 hours of probing growth, was nearly identical to the extant Tokyo rail system, which presumably was the most efficient in practice and took decades to build. [10] The notion that slime molds could apparently make intelligent decisions led inevitably to media hype before settling down to the scientific underpinnings in recent years.

The New York Times proclaimed the wisdom of slime in 2012, noting that it behaved as though it were “extremely intelligent” in creating networks that optimized the transport of nutrients. To promote interest for an American audience, a map of the United States was created with oat flakes marking 20 urban centers with slime mold propagating outward from the simulated location of New York City. The resultant connections nearly replicated the interstate highway system in four separate trials. [11] Broadcast media followed up this somewhat scientific finding with a report that slime mold could “solve problems even though it doesn’t have a brain” and had 720 sexes instead of only the boring two. [12] (Since slime molds don’t have bathrooms or sports teams, their social issues should be manageable). Research on the mechanisms employed by slime molds to locate and exploit food along the most favorable paths continues. The physical process is thought to be similar to the movement of fluids in the intestines, known as peristalsis, with slime mold tubes containing cytoplasmic fluid that surges and retracts in reaction to food quantity and quality. [13] From the perspective of a neurologist, the selection process is called emergence and is similar to the scouting methods used by ants to locate the best nesting site and bees to locate the best food source. In the case of slime molds, tubes are sent in all directions as “scouts” and retracting the unsuccessful paths to flow fully in the food direction. [14] An experiment to evaluate slime mold food preferences is not unlikely.
References:
1. Webster’s Third New International Dictionary of the English Language Unabridged, G. & C. Merriam Company, Philippines, 1971.
2. Roberts, J. Every Living Thing, Random House, New York 2024, pp 45-95.
3. Cazeau, C, Hatcher, R. and Siemankowski, F. Physical Geology, Principles, Processes and Problems, Harper and Row New York 1976, pp 6-11.
4. Starr. C. and Taggart, R. Biology, Wadsworth Publishing Company, Belmont, California, 1989, pp 62, 600-609.
5.Lincoff, G. The Audubon Field Guide to North American Mushrooms, Alfred A. Knopf, New York, 1981, pp 843-854.
6. Kendrick, B. The Fifth Kingdom, Focus Publishing, Newburyport, Massachusetts, 2000. P 10.
7. Keller, H. Everhart, S. and Kilgore, C. “The Myxomycetes: Nature’s Quick-Chage Artists” American Scientist, Volume 112, September-October 2024 pp 352-359.
8. Keller, H, “World Record Myxomycete Fuligo septica Fruiting Body (Aethalium)” Fungi Volume 9 Number 2, September 2016 pp 6-11.
9. Nakagaki, T. et al. “Intelligence: Maze-solving by an amoeboid organism”. Nature. 28 September 2000 Volume 407 Number 6803 page 470.
10. Wogan T. “Ride the Slime Mold Express” Science 21 January 2010.
11. Adamatzky, A and Ilachinski, A, “The Wisdom of Slime” New York Times, 12 May 2012.
12. Zaugg J. “The ‘blob’: Paris zoo unveils unusual organism which can heal itself and has 720 sexes”. CNN. 17 October 2019.
13. Alim, K et al. “Random network peristalsis in Physarum polycephalum organizes fluid flows across an individual”. Proceedings of the National Academy of Science USA. 29 July 2013 Volume 110 Number 33. pp 13306–11.
14. Sapolsky, R. Determined, A Science of Life without Free Will, Penguin Press, New York, 2023, pp 154-166.








